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The patent application WO00/34241 discloses vildagliptin or an acid addition salt thereof, as well as their use in diabetes mellitus and obesity. The patent application WO2006/078593 claims a direct-compression formulation of a DPP-IV inhibitor compound, and preferably of vildagliptin or an acid addition salt thereof.
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Glucagon causes your liver to produce more sugar, so by reducing the amount of glucagon in your body, this also helps to reduce the levels of sugar in your blood. Vildagliptin can be used by itself or alongside other medicines for diabetes, to help control your blood sugar level in different ways. Vildagliptin is available in a combination.
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Patent Application Publication Jul. 10, 2008 US 2008/O167479 A1 O 630 560 49 2O 350 28 210 1400 I Illal. W -Wiwa Maa 2 34 39 44 49 54
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The present invention relates to a pharmaceutical formulation comprising therapeutically effective amount of vildagliptin or pharmaceutically acceptable salt thereof and a diluent. Particularly, the ratio of vildagliptin to diluent is in the range of 0.04 to 0.24 (w/w).
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The present invention relates to a process for preparing vildagliptin of formula (I) with high chemical and enantiomeric purity and compositions comprising vildagliptin. In addition, the present invention relates to (2S,2′S)-1,1′-[[(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)imino]bis(1-oxo-2,1-ethanediyl)]di(2-pyrrolidinecarbonitrile) of formula (II), processes for preparing, and compositions.
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TR2010/10683A 2010-12-21 Vildagliptin formulations. The invention is a pharmaceutical formulation comprising vildagliptin granules having at least one coating layer and one or more excipients. More particularly, the invention relates to a tablet or capsule formulation of vildagliptin with a stable and desired level of solubility and dissolution.
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The reason for the steep fall in price is because Novartis' patent on Vildagliptin is expiring on December 9, 2019, and companies can sell the generic version of the drug, come tomorrow. Vildagliptin is a part of a class of diabetes medications called dipeptidyl peptidase IV or DPP4 inhibitors. According to industry experts, the size of the.
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The present invention relates to a process for preparing vildagliptin of formula (I) with high chemical and enantiomeric purity and compositions comprising vildagliptin. In addition, the present invention relates to (2S,2′S)-1,1′-[[(3-hydroxytricyclo[3.3.1.1 3,7 ]dec-1-yl)imino]bis(1-oxo-2,1-ethanediyl)]di(2-pyrrolidinecarbonitrile) of formula (II), processes for preparing, and.
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Vildagliptin is an amino acid amide. Vildagliptin (LAF237) is an orally active antihyperglycemic agent that selectively inhibits the dipeptidyl peptidase-4 (DPP-4) enzyme. It is used to manage type II diabetes mellitus, where GLP-1 secretion and insulinotropic effects are impaired. By inhibiting DPP-4, vildagliptin prevents the degradation of.
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December 17, 2019 / 09:07 PM IST. The Rs 15,000 crore Indian anti-diabetes drug market is in for a shake-up as companies shift their focus towards promoting the latest generation of SGLT2.
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Vildagliptin (LAF237) is an orally active antihyperglycemic agent that selectively inhibits the dipeptidyl peptidase-4 (DPP-4) enzyme. It is used to manage type II diabetes mellitus, where GLP-1 secretion and insulinotropic effects are impaired. 2 By inhibiting DPP-4, vildagliptin prevents the degradation of glucagon-like peptide 1 (GLP-1) and.
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Justia Patents US Patent Application for Pharmaceutical Formulations of Vildagliptin Patent Application (Application #20170014379) Pharmaceutical Formulations of Vildagliptin . Mar 5, 2015. The present invention relates to a pharmaceutical formulation comprising therapeutically effective amount of vildagliptin or pharmaceutically acceptable.
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The Ό63 patent discloses a synthesis of Vildagliptin using the synthetic process represented in Scheme 1. However, the preparation process of Vildagliptin intermediate, 1-chloro acetyl (S)-2- c ano pyrrolidine has some problems. The acylation of (S)-prolinamide of the formula. with chloroacetyl chloride of the formula.
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The invention is further defined with reference to the following clauses: 1. A combination of vildagliptin or a pharmaceutically acceptable salt thereof, and metformin or a pharmaceutically acceptable salt thereof, for use in a method of delaying loss of glycaemic control in a patient with type 2 diabetes mellitus. 2.
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NOVARTIS AG (CH) Country. Cyprus. Dates. Priority: 2005/09/29. Description. This web page summarizes information in PubChem about patent CY-1112305-T1. This includes chemicals mentioned, as reported by PubChem contributors, as well as other content, such as title, abstract, and International Patent Classification (IPC) codes.
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US-2017014379-A1 chemical patent summary.