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Recently, the emerging role of the oncoprotein B cell lymphoma 6 (BCL6) in tumorigenesis and stress response has been unveiled. Here, we demonstrate that BCL6 was upregulated upon BET inhibition in KRAS-mutant cancers, including non-small-cell lung cancer (NSCLC). We further found that BRD3, not BRD2 or BRD4, directly interacted with BCL6 and.
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Human alpha/beta hydrolase domain 6 (hABHD6) is an enzyme that hydrolyzes 2-arachidonoylglycerol (2-AG), a potent agonist at both cannabinoid CB1 and CB2 receptors. In vivo modulation of ABHD6.
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To find the domain of a function, consider any restrictions on the input values that would make the function undefined, including dividing by zero, taking the square root of a negative number, or taking the logarithm of a negative number. Remove these values from the set of all possible input values to find the domain of the function.
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TBX21. T-box transcription factor TBX21, also called T-bet (T-box expressed in T cells) is a protein that in humans is encoded by the TBX21 gene. [5] Though being for long thought of only as a master regulator of type 1 immune response, T-bet has recently been shown to be implicated in development of various immune cell subsets and maintenance.
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Background & aims: T cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3) has been shown to influence autoimmune diseases; however, its function in viral infection has not been well-defined. We therefore investigated the expression and regulatory function of Tim-3 in natural killer (NK) cells in chronic Hepatitis B (CHB) infection.
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The Beechcraft T-6 Texan II is a single-engine turboprop aircraft built by the Raytheon Aircraft Company (Textron Aviation since 2014). A trainer aircraft based on the Pilatus PC-9, the T-6 replaced the United States Air Force's Cessna T-37B Tweet and the United States Navy's T-34C Turbo Mentor during the 2010s.. The T-6A is used by the United States Air Force for basic pilot training and.
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T-bet is a recently appreciated transcription factor associated with "Age-associated B cells" or ABCs, the development of autoimmunity, and viral infections. T-bet expression is favored by nucleic acid-containing antigens and immune complexes and is regulated by interplay between various cytokines, notably, the TFH cytokines IL-21, IL-4 and.