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Papaverine (Latin papaver, "poppy") is an opium alkaloid antispasmodic drug, used primarily in the treatment of visceral spasms and vasospasms (especially those involving the intestines, heart, or brain), occasionally in the treatment of erectile dysfunction and acute mesenteric ischemia.While it is found in the opium poppy, papaverine differs in both structure and pharmacological action from.
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Papaverine Hydrochloride, USP, is 6,7-dimethoxy-1- veratrylisoquinoline hydrochloride and contains, on the dried basis, not less than 98.5% of C 20 H 21 NO 4 •HCI. The molecular weight is 375.85. The structural formula is as shown. Papaverine Hydrochloride occurs as white crystals or white crystalline powder. One gram dissolves in about 30 mL.
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Papaverine may cause serious side effects. Call your doctor at once if you have: upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); skin rash, bruising, severe tingling, numbness, pain, muscle weakness; severe headache, blurred vision, fast heart rate, pounding in your neck or ears.
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Papaverine comes as a tablet and extended-release (long-acting) capsule to take by mouth. The tablet usually is taken three to five times a day at evenly spaced intervals. The extended-release capsule usually is taken every 8-12 hours. Do not crush, chew, or divide the extended-release capsules.
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Papaverine is a vasodilator. It works by relaxing the muscles in the blood vessels.Papaverine is also an antiarrhythmic medication that treats certain abnormal heartbeats (ventricular arrhythmias). It works by blocking the abnormal electrical activity in the heart so a normal heart beat can return.
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Biasanya kekuatan dosis ini tergantung pada kondisi medis, usia, dan berat badan seseorang. Aturan pakai mengacu pada bagaimana produk kesehatan tersebut digunakan atau dikonsumsi. Berikut ini dosis dan aturan pakai Papaverine: Dewasa : 3 kali sehari 1-2 tablet. Anak-anak : 2,5 mg/kg berat badan dalam 4 dosis terbagi.
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Berikut ini dosis yang umum dokter berikan: Papaverine HCL bentuk kapsul extended-release: Dewasa: 150 miligram (mg) setiap 12 jam. Dosis dapat ditingkatkan menjadi 150 mg setiap 8 jam atau 300 mg setiap 12 jam. Papaverine HCL bentuk tablet: Dewasa: 100 hingga 300 mg sebanyak 3 - 5 kali sehari.
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Papaverine Hydrochloride Injection, USP, is a clear, colorless to pale-yellow solution. Papaverine Hydrochloride, for parenteral administration, is a smooth-muscle relaxant that is available in vials containing 30 mg/mL. Each vial also contains edetate disodium 0.005%. The 10 mL vials also contain chlorobutanol 0.5% as a preservative. pH may be.
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Papaverine hydrochloride was selected as the model drug. It is well-soluble in acidic medium and its solubility increases proportionally with the decrease in pH of the medium [20, 21]. Papaverine hydrochloride is a spasmolytic drug which can be found in opium as its main isoquinoline alkaloid. It is used in bile, intestinal, and renal spikes.
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Efek samping umum yang mungkin terjadi dari penggunaan papaverine, antara lain: Mual, sakit perut, kehilangan nafsu makan, sembelit, diare. Nyeri. Sakit kepala, mengantuk, pusing atau sensasi berputar. Ruam kemerahan disertai sensasi hangat pada kulit. Ruam kulit. Peningkatan keringat. Kelelahan dan kurang energi.
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Do not add papaverine hydrochloride injection to lactated Ringer's injection because a precipitate would result. Actions. Main therapeutic action is a direct spasmolytic effect on smooth muscles. Spasmolytic effect most pronounced on blood vessels including the coronary, cerebral, pulmonary, and peripheral arteries; also relaxes smooth.
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Papaverine Hcl side effects. Serious Side Effects. Yellowing of the skin or the whites of your eyes. Severe diarrhea, vomiting, or stomach pain. Dark colored urine. Fast heartbeat. Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing.
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Papaverine Hydrochloride may be administered intravenously or intramuscularly. The intravenous route is recommended when an immediate effect is desired, but the drug must be injected slowly over the course of 1 or 2 minutes to avoid uncomfortable or alarming side effects. Parenteral administration of papaverine hydrochloride in doses of 1 to 4.
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Papaverine hydrochloride is equally as effective as sodium diclofenac for the short-term relief of acute renal colic pain, and it may be advantageous in patients with contraindications according to a prospective, single-blind clinical study that involved 86 patients with acute renal colic who were given 120 mg intravenous papaverine hydrochloride .
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Identification Summary. Papaverine is an alkaloid used to treat many types of smooth muscle spasms such as "vascular spasms" associated with acute myocardial infarction and angina pectoris, as well as "visceral spasms".. Generic Name Papaverine DrugBank Accession Number DB01113 Background. An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or.
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Descriptions. Papaverine belongs to the group of medicines called vasodilators. Vasodilators cause blood vessels to expand, thereby increasing blood flow. This medicine is used to treat problems resulting from poor blood circulation. Papaverine is available only with your doctor's prescription.