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JNT-517 is a Potential First-in-Class Oral Treatment for PKU; Phase 1b Study Follows Positive Clinical Proof of Mechanism Data in Healthy Individuals Upcoming Oral Presentation of Phase 1a Study Results at the Society for the Study of Inborn Errors of Metabolism (SSIEM) Annual Symposium 2023 BOSTON, August 9, 2023 - Jnana Therapeutics,a clinical-stage biotechnology company…
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JNT-517 is a selective small molecule inhibitor of the phenylalanine transporter SLC6A19 that has the potential to be a first-in-class oral therapy used to treat any person with PKU, regardless of age or genotype. JNT-517 acts at a novel, cryptic allosteric site to block kidney reabsorption of Phe and offers a promising new approach to reduce.
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J&T Express is an international delivery company founded in August 2015 in Jakarta, Indonesia. Its core business is express services and cross-border logistics. J&T Express is committed to continuously creating integrated quality experiences for its customers globally. With over 300,000 service personnels worldwide, J&T Express' network spans.
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Beginning its official activities in 1985, which coincided with the fifteenth year of the journal's publication, JNT became the official organ of that new society, with an expansion of the Editorial Board beyond members of Eastern's English department. In 1986 the Society began a series of annual spring conferences, initially with some.
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Series C financing led by Bain Capital Life Sciences to support PKU program and pipeline in immune-mediated diseases and cancer; Ron Renaud joins Jnana's Board of Directors Jnana initiates Phase 1 clinical trial of JNT-517, a potential first-in-class oral treatment for PKU; JNT-517 receives US FDA Rare Pediatric Disease Designation BOSTON, Mass., November 15, 2022…
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About JNT-517 JNT-517 is a selective small molecule inhibitor of the phenylalanine transporter SLC6A19 that has the potential to be a first-in-class oral therapy used to treat any person with PKU.
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JNT-517 was derived from an allosteric inhibitor series identified by RAPID. A proprietary cryo-EM structure of SLC6A19 in complex with a Jnana proprietary compound has revealed that Jnana's allosteric inhibitors bind in an unprecedented cryptic allosteric site on the SLC transporter. Immune-Mediated Diseases. Undisclosed.
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About JNT-517 JNT-517 is a selective small molecule inhibitor of the phenylalanine transporter SLC6A19 that has the potential to be a first-in-class oral therapy used to treat any person with PKU.
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All participants in Part C will receive JNT-517. The goal of Part D is to assess the safety, tolerability, PK, and effect on urinary Phe and other amino acids of JNT-517 in participants with phenylketonuria (PKU). Participants in Part D will receive either JNT-517 or placebo and will be blinded to their treatment assignment.
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Treatment with JNT-517 demonstrated a statistically significant mean blood phenylalanine reduction of 51% versus baseline JNT-517 was safe and well tolerated with no serious adverse events Jnana has adapted the ongoing trial to accelerate the program and aims to advance JNT-517 directly into a pivotal study in early 2025 BOSTON, January 30, 2024 - Jnana…