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Obat ini juga digunakan dengan aspirin untuk bantu mengobati memburuknya nyeri dada (serangan jantung baru, tidak stabil angina), menjaga pembuluh darah terbuka, serta mencegah pembekuan darah pasca-prosedur tertentu (misalnya stent jantung).
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Clopidogrel merupakan pengencer darah, yang bekerja dengan menghambat pelekatan trombosit dan penyumbatan berbahaya. Clopidogrel digunakan untuk mengurangi kejadian trombolitik pada infark miokard yang belum lama terjadi, stroke, atau penyakit arteri perifer, sindrom koroner akut.
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Clopidogrel termasuk kategori obat yang memiliki sifat polimorfisme. Dua bentuk polimorfik Clopidogrel telah diidentifikasi dan ditetapkan sebagai Form 1 dan Form 2. Form 1 dan Form 2 memiliki indikasi yang sama. Perbedaan antara dua bentuk kristal terletak pada susunan kation Clopidogrel dan anion sulfat.
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Clopidogrel is an inactive prodrug that requires enzymatic activation via a variety of CYP enzymes, including the CYP2C19 and CYP3A4 enzymes, through a two-step process of bioactivation. Genetic polymorphisms to these enzymes can influence response to therapy.
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Absorption. A 75mg oral dose of clopidogrel is 50% absorbed from the intestine. 9 Clopidogrel can be taken with or without food. 9 A meal decreases the AUC of the active metabolite by 57%. 9 The active metabolite of clopidogrel reaches a maximum concentration after 30-60 minutes. 9 Clopidogrel reached a C max of 2.04±2.0ng/mL in 1.40±1.07h. 5 The AUC for a 300mg oral dose of clopidogrel was.
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Kimia Farma | CLOPIDOGREL Home CLOPIDOGREL KELAS TERAPI : ANTIKOAGULAN KOMPOSISI : Tiap tablet mengandung : Clopidrogel 75 mg KEMASAN : Dus, 3 strip @ 10 tablet Womens Running Shoes & Running Clothes Kimia Farma adalah perusahaan industri farmasi pertama dan terbesar di Indonesia yang didirikan sejak tahun 1817.
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Clopidogrel is used to prevent heart attacks and strokes in persons with heart disease (recent heart attack), recent stroke, or blood circulation disease (peripheral vascular disease).. Clopidogrel is also used with aspirin to treat new/worsening chest pain (new heart attack, unstable angina) and to keep blood vessels open and prevent blood clots after certain procedures (such as cardiac stent).
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Clopidogrel oral tablet is a prescription drug that's available as the brand-name drug Plavix.It's also available as a generic drug. Generic drugs usually cost less than the brand-name version.
Clopidogrel a cosa serve e quali sono gli effetti collaterali?
Clopidogrel (Plavix) Clopidogrel (Plavix®) is an antiplatelet drug you can take to prevent blood clots. It keeps platelets in your blood from coming together and making clots. You may need clopidogrel to prevent future issues if you had a heart attack, stroke or certain types of heart surgery. Additional Common Questions.
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Clopidogrel slows the blood's clotting action by making platelets less sticky. Platelets are blood cells that stick together to block cuts and breaks in blood vessels. But if you're at risk of heart attack or stroke, platelets can stick together inside already narrowed blood vessels to form a clot. The clot can stop blood flowing to the heart.
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Methods. The study included patients receiving either a single 300 mg loading dose of clopidogrel (n = 17) or a 75 mg dose (n = 45) for at least 7 days before sample collection.The concentrations of clopidogrel and its metabolites—the inactive H3 and the pharmacologically active H4 isomers of the thiol metabolite and the inactive carboxylic acid metabolite—in plasma samples (stabilized.
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2. Clopidogrel pharmacokinetics and pharmacodynamics. Following oral administration, about 50% of the dose is absorbed from the intestine based on urinary metabolites data [].Results from in vitro studies show that the uptake of clopidogrel into Caco-2 cells is limited by P-glycoprotein (P-gp, ABCB1), which suggests that P-gp may affect the intestinal absorption and oral bioavailability of.
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Clopidogrel may not work as well if you have certain genetic factors that affect the breakdown of this medicine in your body. Your doctor may perform a blood test to make sure clopidogrel is right for you. This medicine is not expected to harm an unborn baby. However, taking clopidogrel within 1 week before childbirth can cause bleeding in the.
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Kimia Farma Sungwun Pharmacopia Cikarang, Indonesia Clopidogrel Bi-sulphate Form II API Products Clopidogrel Bi-sulphate Form II Classification: Anti-Platelet CAS: 120202-66-6 Pack Type: HDPE Drum 20 kg Certified: GMP and Halal MUI MoQ (Minimum of Quantity) Purchase: 1 kg For more info regarding specifications, please inquire us here
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The typical dosage of clopidogrel is 75 milligrams (mg) taken once daily. For people with acute coronary syndrome, doctors typically recommend a one-time loading dose of 300 mg on the first day of.