1 Gm Seftizox Ceftizoxime Injection at Rs 900/vial Ceftizoxime Injection in Hyderabad ID
Cefizox (ceftizoxime injection) in the Galaxy ® plastic container is a frozen iso-osmotic, sterile, nonpyrogenic premixed 50 mL solution containing 1 g or 2 g of ceftizoxime as ceftizoxime sodium. Dextrose, USP has been added to these dosages to adjust osmolality (approximately 1.9 g and 950 mg to the 1 g and 2 g dosages as dextrose hydrous, respectively).
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Mechanism of action. Ceftizoxime is an aminothiazolyl cephalosporin with an extended spectrum of activity against many gram-negative, nosocomially acquired pathogens. It has excellent beta-lactamase stability, with good in vitro activity against Haemophilus influenzae, Neisseria gonorrhoeae and Klebsiella pneumoniae.
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Ceftizoxime is an iminomethoxy aminothiazolyl cephalosporin that inhibits a wide variety of aerobic, anaerobic gram-positive and gram-negative bacteria. The majority of Enterobacteriaceae are inhibited by less than or equal to 1 microgram/ml as are streptococcal species with the exception of Strepto.
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Ceftizoxime. Ceftizoxime adalah antibiotik yang digunakan untuk mengobati berbagai penyakit akibat infeksi bakteri, seperti gonore dan infeksi saluran kemih. Obat ini hanya dapat digunakan dengan resep dokter. Ceftizoxime termasuk antibiotik golongan sefalosporin generasi ketiga yang tersedia dalam bentuk suntik.
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Ceftizoxime falls into category B: There are no well-done studies that have been done in humans with Ceftizoxime. But in animal studies, pregnant animals were given this medication, and the babies did not show any medical issues related to this medication. OR. In animal studies, pregnant animals were given Ceftizoxime, and some babies had problems.
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Patel et al. compared the serum bactericidal titers (SBTs) and the time serum drug concentrations remained above the MICs (T > MIC) of ceftizoxime and cefotaxime against three intermediately penicillin-resistant Streptococcus pneumoniae isolates.MICs were ≤ 1.0 μg/ml, SBTs were > 1:2, and T > MIC exceeded 50% of dosage intervals. They concluded that ceftizoxime's longer T > MIC.
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Ceftizoxime concentrations are higher in cord blood and AF than in maternal blood, perhaps because of more avid binding to fetal serum proteins. It is the only antibiotic known to have such high transfer. Rodent studies are reassuring, revealing no evidence of teratogenicity or IUGR despite the use of doses higher than those used clinically..
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Ceftizoxime is a parenteral, third-generation cephalosporin antibiotic used to treat bacterial infections including ear, nose, and throat infections. These pectin-based nanocarriers were spherical with a size range of 70 to 90 nm where the drug molecule is entrapped within the pectin gel.
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Cefizox (ceftizoxime injection) in the Galaxy ® plastic container is a frozen iso-osmotic, sterile, nonpyrogenic premixed 50 mL solution containing 1 g or 2 g of ceftizoxime as ceftizoxime sodium. Dextrose, USP has been added to these dosages to adjust osmolality (approximately 1.9 g and 950 mg to the 1 g and 2 g dosages as dextrose hydrous, respectively).
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fever, chills, body aches, flu symptoms; easy bruising or bleeding, unusual weakness; fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; seizure (black-out or convulsions); or. jaundice (yellowing of the eyes or skin). Less serious side effects are more likely to occur, such as:
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Ceftizoxime is a 'third generation' cephalosporin administered intravenously or intramuscularly. Like other third generation cephalosporins it has a wide spectrum of in vitro activity against Gram-positive and Gram-negative bacteria, is particularly active against Enterobacteriaceae (including beta-lactamase-positive strains), and is resistant to hydrolysis by beta-lactamases.
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Synopsis: Ceftizoxime 1 is a 'third generation' cephalosporin administered intravenously or intramuscularly. Like other third generation cephalosporins it has a wide spectrum of in vitro activity against Gram-positive and Gram-negative bacteria, is particularly active against Enterobacteriaceae (including β-lactamase-positive strains), and is resistant to hydrolysis by β-lactamases.
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CEFIZOX® SmithKline Beecham . Ceftizoxime Sodium . Antibiotic . Action And Clinical Pharmacology: In vitro studies indicate that the bactericidal action of ceftizoxime results from inhibition of cell-wall synthesis in aerobic and anaerobic gram-positive and gram-negative organisms. In vitro, ceftizoxime shows a strong affinity for penicillin-binding proteins 1a, 1bs and 3 of E. coli.
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It has the following structural formula: C 12 H 12 N 5 NaO 5 S 2 405.38. Ceftizoxime for injection, USP is a white to pale yellow crystalline powder. Cefizox is supplied in vials equivalent to 500 mg, 1 gram or 2 grams of ceftizoxime, and in Piggyback Vials for IV admixture equivalent to 1 gram or 2 grams of ceftizoxime.
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Ceftizoxime is a third-generation cephalosporin available for parenteral administration. [1] Unlike other third-generation cephalosporins, the whole C-3 side chain in ceftizoxime has been removed to prevent deactivation by hydrolytic enzymes . It rather resembles cefotaxime in its properties, but is not subject to metabolism.
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The usual adult dosage is 1 or 2 grams of Cefizox (ceftizoxime injection) in Galaxy ® plastic container every 8 to 12 hours. Proper dosage and route of administration should be determined by the condition of the patient, severity of the infection, and susceptibility of the causative organisms. General Guidelines for Dosage of Cefizox.